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AdipoGen Jagged-1 msFc h rec
Supplier: AdipoGen AG40A0157TC050
Protein. Signal peptide and extracellular domain of mouse Jagged-1 aa 1-1067 are fused at the C-terminus to the Fc portion of human IgG. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >90% SDS-PAGE. Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis in vitro. Defects in Jagged-1 are the cause of Alagille syndrome type 1 ALGS1 and tetralogy of Fallot TOF.
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