Jatrorrhizine Hydrochloride (CAS No 960383-96-4) is a protoberberine alkaloid with significant biomedical research interest due to its potential therapeutic applications Originating from the plant Coptis chinensis jatrorrhizine is known for influencing key biological pathways including inhibition of the NF- B signaling pathway which is crucial in inflammation and cancer proliferation Its activity is commonly observed in the nanomolar to low micromolar range in vitro indicating potent efficacy at low concentrations Typical research applications include studies involving cell models and animal studies particularly focusing on anti-inflammatory and anticancer effects Moreover it is frequently utilized in drug screening assays to explore novel therapeutic agents Experimental concentrations typically depend on the specific research design allowing flexibility in determining its utility across various experimental setups