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Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 100 MG
Supplier: Medchemexpress LLC HY151500B100MG
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT), with IC50 values for human, mouse, and monkey NNMT of 33, 210, and 190 nM, respectively. It reduces endogenous MNA levels in U2OS cells (EC50 2.5 μM) and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. It is suitable for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells (EC50 2.5 μM).
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Binds below a hairpin structural motif at the nicotinamide pocket.
- Inactive against a broad panel of metabolism-related targets.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Enhances glucose tolerance in NNMT knockout DIO mice.
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