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Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY151500B

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JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT). It demonstrates anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model, suitable for research into metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.

  • Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT)
  • Reduces endogenous MNA levels in U2OS osteosarcoma cells with an EC50 of 2.5 μM
  • Exhibits anti-obesity and anti-diabetic activities in diet-induced obesity (DIO) model
  • Useful for studying metabolic diseases (obesity, type 2 diabetes, non-alcoholic fatty liver disease)
  • IC50 values for NNMT: 33 nM (human), 210 nM (mouse), 190 nM (monkey)

Catalog No. 50-003-74231


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