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Medchemexpress LLC Jbsnf-000028 Tfa | C13H14F3N3O2 | 1 ML
Supplier: Medchemexpress LLC HY151500A10MM/1ML
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. It can reduce endogenous MNA levels in U2OS osteosarcoma cells, with an EC50 of 2.5 μM. This compound exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model and can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of NNMT
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Exhibits anti-obesity and anti-diabetic activities
- Useful for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease
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