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Medchemexpress LLC Jbsnf-000028 tfa | C13H14F3N3O2 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY151500A

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JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It reduces endogenous MNA levels in U2OS osteosarcoma cells and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. This compound is suitable for research into metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.

  • Inhibits NNMT activity in U2OS cells with an EC50 of 2.5 μM.
  • Shows no cytotoxicity against HepG2 cells at concentrations of 10-100 μM.
  • Improves glucose and lipid handling in diet-induced obese mice.
  • Enhances glucose tolerance in NNMT knockout mice with diet-induced obesity.

Catalog No. 50-003-74369


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