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Medchemexpress LLC Jbsnf-000028 TFA | C13H14F3N3O2 | 5 MG
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Supplier:  Medchemexpress LLC HY151500A5MG

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JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models and is used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.

  • Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT).
  • Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells.
  • Shows no cytotoxicity against HepG2 cells at 10-100 μM.
  • Improves glucose and lipid handling in mice with diet-induced obesity.
  • Improves glucose tolerance in NNMT knockout mice with diet-induced obesity.

Catalog No. 50-003-72310


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