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Medchemexpress LLC JH-II-127 | 1700693-08-8 | 98.0% | 416.86 | 1 ML
Supplier: Medchemexpress LLC HY1693610MM/1ML
JH-II-127 is an orally active, highly potent, selective, and brain-permeable LRRK2 inhibitor. It has IC50s of 6, 2, and 48 nM for wild-type LRRK2, LRRK2-G2019S, and mutant LRRK2-A2016T, respectively. This compound inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be utilized in the study of Parkinson's syndrome.
- CAS No.: 1700693-08-8
- Molecular weight: 416.86
- Purity: 98.0%
- Appearance: Solid
- Color: Light yellow to yellow
- Formula: C19H21ClN6O3
- Solubility in vitro: DMSO: 110 mg/mL (263.88 mM)
- Solubility in vivo dissolution protocols available
- Shipping: Room temperature in continental US
- Storage: Powder: -20°C for 3 years, 4°C for 2 years; In solvent: -80°C for 2 years, -20°C for 1 year
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