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Medchemexpress LLC JH-II-127 | 1700693-08-8 | 98.0% | 416.86 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1693650MG

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JH-II-127 is an orally active, highly potent, selective, and brain-permeable LRRK2 inhibitor, with IC50s of 6 nM for wild-type LRRK2, 2 nM for LRRK2-G2019S, and 48 nM for mutant LRRK2-A2016T. It inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of Parkinson's syndrome.

  • Orally active, highly potent, selective, and brain-permeable LRRK2 inhibitor
  • Inhibits Ser935 phosphorylation in all tissues of mice, including the brain
  • Can be used in the study of Parkinson's syndrome
  • Demonstrated good oral bioavailability in vivo

Catalog No. 50-003-91307


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