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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 10 MG
Supplier: Medchemexpress LLC HY11214010MG
JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK variants, including those with resistance mutations, and shows selectivity against other kinases. This compound inhibits the growth of several cancer cell lines and exhibits good oral bioavailability, with the ability to penetrate the central nervous system in mice.
- Potent inhibitor of EML4-ALK variants, including G1202R resistance mutation
- Selective against various other kinases such as IRAK1, CLK4, and RET
- Inhibits the growth of cancer cell lines like H3122 and DFCI76
- Good oral bioavailability in mice
- Penetrates the central nervous system in mice
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