Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 100 MG

Supplier:  Medchemexpress LLC HY112140100MG

JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for EML4-ALK G1202R in cells and potently inhibits various other EML4-ALK mutants and wild type (e.g., EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y with IC50s of 2-196 nM). It shows selectivity at other kinases like IRAK1, CLK4, RET, and IRAK 4. JH-VIII-157-02 demonstrates inhibitory growth against cancer cell lines like H3122 and DFCI76 (EC50s of 5 nM and 19 nM). It also has good oral bioavailability and penetrates the CNS in mice.

• Structural analogue of alectinib
• Acts as an ALK inhibitor
• Shows potent inhibition of EML4-ALK G1202R mutant (IC50 of 2 nM)
• Potently inhibits other EML4-ALK mutants and wild type
• Exhibits selectivity at several other kinases
• Inhibits growth of cancer cell lines
• Good oral bioavailability in mice
• Penetrates the CNS of mice

Catalog No. 50-004-36954