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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
Supplier: Medchemexpress LLC HY11214050MG
JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
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