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Medchemexpress LLC JH-X-119-01 hydrochloride | 2591344-30-6 | 99.1% | 488.93 | 10 MG
Supplier: Medchemexpress LLC 10MGHY103017
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. It ameliorates LPS-induced sepsis in mice by decreasing phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. It selectively inhibits IRAK1 phosphorylation. In vivo, it improves survival and decreases immunopathies of LPS-challenged mice, increasing survival at doses of 5 mg/kg and 10 mg/kg body weight.
- Potent and selective IRAK1 inhibitor
- Ameliorates LPS-induced sepsis in mice
- Decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro
- Selectively inhibits IRAK1 phosphorylation
- Improves survival and decreases immunopathies in LPS-challenged mice
- For research use only
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