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Medchemexpress LLC JH-XI-10-02 | 2209085-22-1 | 99.7% | 920.14 | 25 MG
SDP

Catalog No. 5000346735
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JH-XI-10-02 is a PROTAC that connects ligands for Cereblon and CDK. It is a highly potent and selective PROTAC CDK8 degrader with an IC50 of 159 nM. This compound causes proteasomal degradation and does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

  • Highly potent and selective PROTAC CDK8 degrader.
  • Causes proteasomal degradation.
  • Does not affect CDK8 mRNA levels.
  • Shows no effect on CDK19.
  • Induces partial degradation of CDK8 in Jurkat cells after 6 hours and significant degradation after 24 hours at 1 μM.
  • Induces degradation of CDK8 at 5 μM in WT Molt4 cells, but not in CRBN null Molt4 cells.

Catalog No. 50-003-46735 Supplier Medchemexpress LLC Supplier No. 25MGHY111518
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JH-XI-10-02 is a PROTAC that connects ligands for Cereblon and CDK. It is a highly potent and selective PROTAC CDK8 degrader with an IC50 of 159 nM. This compound causes proteasomal degradation and does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

  • Highly potent and selective PROTAC CDK8 degrader.
  • Causes proteasomal degradation.
  • Does not affect CDK8 mRNA levels.
  • Shows no effect on CDK19.
  • Induces partial degradation of CDK8 in Jurkat cells after 6 hours and significant degradation after 24 hours at 1 μM.
  • Induces degradation of CDK8 at 5 μM in WT Molt4 cells, but not in CRBN null Molt4 cells.

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