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Medchemexpress LLC JIB-04 | 199596-05-9 | 98.3% | 308.76 | 1 ML
SDP

Catalog No. 5000350183
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JIB-04 is a pan-selective Jumonji histone demethylase inhibitor. It exhibits IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. It is intended for research use only.

  • Is consistently selective for cancer versus normal cells.
  • Inhibits cellular Jumonji demethylase activity.
  • Significantly inhibits the proliferation of glioblastoma cell lines.
  • Exerts maximal inhibitory activity against KDM5A.
  • Modulates the expression of genes involved in cancer cell growth.
  • Leads to hypermethylation of H3K4.
  • Activates autophagy and apoptotic pathways.
  • Inactivates PI3K.
  • Cooperates with temozolomide in killing glioblastoma cells.
  • Results in a significant reduction in cancer-induced death rates in mice, prolonging survival.

Catalog No. 50-003-50183 Supplier Medchemexpress LLC Supplier No. HY1395310MM/1ML
May include imposed supplier surcharges.
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JIB-04 is a pan-selective Jumonji histone demethylase inhibitor. It exhibits IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. It is intended for research use only.

  • Is consistently selective for cancer versus normal cells.
  • Inhibits cellular Jumonji demethylase activity.
  • Significantly inhibits the proliferation of glioblastoma cell lines.
  • Exerts maximal inhibitory activity against KDM5A.
  • Modulates the expression of genes involved in cancer cell growth.
  • Leads to hypermethylation of H3K4.
  • Activates autophagy and apoptotic pathways.
  • Inactivates PI3K.
  • Cooperates with temozolomide in killing glioblastoma cells.
  • Results in a significant reduction in cancer-induced death rates in mice, prolonging survival.

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