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Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MM 1 ML
Supplier: Medchemexpress LLC HYU00433A10MM/1ML
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. It does not induce intracellular calcium mobilization. Studies show it dose-dependently decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI), also blocking Phencyclidine (PCP)-induced deficits.
- GHSR-1a antagonist (IC50 of 32±3 nM)
- No intracellular calcium mobilization
- Dissociation constant (Kb) of 19±6 nM
- Decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI)
- Blocks PCP-induced PPI deficits
- Relevant for neurological disease and endocrinology research
- Store at 4°C (sealed, away from moisture) or in solvent at -80°C (6 months) / -20°C (1 month)
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