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Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 50 MG
Supplier: Medchemexpress LLC HY15318850MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It induces apoptosis, increases the expression of cleaved PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- IC50s of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP
- Induces apoptosis and increases cleaved PARP expression
- Decreases expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)
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