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Apexbio Technology LLC JNJ-26854165 (Serdemetan) 881202-45-5 5mg
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Catalog No. 5000062580
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JNJ-26854165 (Serdemetan CAS 881202-45-5) is a small-molecule antagonist targeting human double minute-2 (HDM-2) ubiquitin ligase originally developed as a p53 activator Mechanistically JNJ-26854165 disrupts the association between HDM-2 client protein complexes and the proteasome resulting in elevated levels of downstream HDM-2 substrates such as p53 In preclinical studies using multiple tumor models with either wild-type or mutant p53 this compound exhibited potent antiproliferative activity and apoptotic induction In vivo xenograft studies showed significant event-free survival benefits across numerous solid tumor and acute lymphoblastic leukemia models suggesting potential utility in oncology research

Catalog No. 50-000-62580 Supplier Apexbio Technology LLC Supplier No. A42045
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JNJ-26854165 (Serdemetan CAS 881202-45-5) is a small-molecule antagonist targeting human double minute-2 (HDM-2) ubiquitin ligase originally developed as a p53 activator Mechanistically JNJ-26854165 disrupts the association between HDM-2 client protein complexes and the proteasome resulting in elevated levels of downstream HDM-2 substrates such as p53 In preclinical studies using multiple tumor models with either wild-type or mutant p53 this compound exhibited potent antiproliferative activity and apoptotic induction In vivo xenograft studies showed significant event-free survival benefits across numerous solid tumor and acute lymphoblastic leukemia models suggesting potential utility in oncology research

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