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Apexbio Technology LLC JNJ-38877605 943540-75-8 5mg
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Catalog No. 5000093494
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JNJ-38877605 (CAS 943540-75-8) is an ATP-competitive small molecule inhibitor targeting the catalytic activity of c-Met receptor tyrosine kinase Comparative in vitro kinase profiling demonstrates approximately 600-fold selectivity for c-Met over a panel of around 250 other tyrosine and serine/threonine kinases effectively inhibiting both HGF-stimulated and constitutive c-Met phosphorylation In vivo JNJ-38877605 exhibits complete oral bioavailability across studied species and sustains inhibition of Met phosphorylation for up to 16 hours in tumor xenograft models with tumor growth suppression correlating with the extent of Met inhibition It has further undergone safety and dosing evaluation in patients with advanced or refractory solid tumors

Catalog No. 50-000-93494 Supplier Apexbio Technology LLC Supplier No. A50925
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JNJ-38877605 (CAS 943540-75-8) is an ATP-competitive small molecule inhibitor targeting the catalytic activity of c-Met receptor tyrosine kinase Comparative in vitro kinase profiling demonstrates approximately 600-fold selectivity for c-Met over a panel of around 250 other tyrosine and serine/threonine kinases effectively inhibiting both HGF-stimulated and constitutive c-Met phosphorylation In vivo JNJ-38877605 exhibits complete oral bioavailability across studied species and sustains inhibition of Met phosphorylation for up to 16 hours in tumor xenograft models with tumor growth suppression correlating with the extent of Met inhibition It has further undergone safety and dosing evaluation in patients with advanced or refractory solid tumors

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