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Medchemexpress LLC Jnj-61803534 | 1917306-14-9 | 99.8% | 622.41 | 1 ML
SDP

Catalog No. 5000351216
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JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6 nM. It exhibits anti-inflammatory activity and inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. It also inhibits RORγt transcription in HEK-293 T cells.

  • Potent and orally active RORγt inverse agonist.
  • IC50 of 9.6 nM against RORγt.
  • Anti-inflammatory activity.
  • Inhibits IL-17A, IL-17F, IFNγ, and IL-22 production in CD4+ T cells.
  • Alleviates inflammation, cartilage damage, bone destruction in mouse collagen-induced arthritis (CIA) model.
  • Alleviates Imiquimod-induced dermal psoriatic-like inflammation in mice.

Catalog No. 50-003-51216 Supplier Medchemexpress LLC Supplier No. HY13978010MM/1ML
May include imposed supplier surcharges.
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JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6 nM. It exhibits anti-inflammatory activity and inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. It also inhibits RORγt transcription in HEK-293 T cells.

  • Potent and orally active RORγt inverse agonist.
  • IC50 of 9.6 nM against RORγt.
  • Anti-inflammatory activity.
  • Inhibits IL-17A, IL-17F, IFNγ, and IL-22 production in CD4+ T cells.
  • Alleviates inflammation, cartilage damage, bone destruction in mouse collagen-induced arthritis (CIA) model.
  • Alleviates Imiquimod-induced dermal psoriatic-like inflammation in mice.

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