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Apexbio Technology LLC JNJ-7706621 443797-96-4 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A41155.1

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JNJ-7706621 (CAS 443797-96-4) is an inhibitor targeting cyclin-dependent kinases (CDKs) and Aurora kinases specifically CDK1 (IC50 0 009 mol/L) CDK2 (0 004 mol/L) CDK3 (0 003 mol/L) CDK4 (0 058 mol/L) CDK6 (0 253 mol/L) Aurora A (0 011 mol/L) and Aurora B (0 015 mol/L) It selectively reduces proliferation of tumor cells relative to normal human cells with approximately 10-fold higher specificity Independent of cellular status of p53 retinoblastoma protein or p-glycoprotein expression JNJ-7706621 induces apoptosis suppresses colony formation and inhibits growth highlighting its utility in cancer research

Catalog No. 50-000-61434


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