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Medchemexpress LLC (+)-JNJ-A07 | 2135640-93-4 | 98.5% | 578.96 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139602
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3-NS4B interaction. It demonstrates nanomolar to picomolar activity against a panel of 21 clinical isolates. The compound possesses a favorable pharmacokinetic profile, leading to outstanding efficacy against dengue virus infection in mouse infection models.
- Exhibits a high barrier to resistance
- Prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B)
- Potent and orally active pan-serotype dengue virus inhibitor
- Effective against a panel of 21 clinical isolates
- Favorable pharmacokinetic profile
- Outstanding efficacy against dengue virus infection in mouse models
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