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Medchemexpress LLC JNJ28871063 hydrochloride | 944342-90-9 | 98.4% | 519.42 | C24H28Cl2N6O3 | 25 MG
Supplier: Medchemexpress LLC HY10344125MG
JNJ28871063 hydrochloride (CAS 944342-90-9) is an orally active, ATP-competitive pan-ErbB kinase inhibitor used in research to probe EGFR/ErbB2/ErbB4 signaling and oncology models. It inhibits phosphorylation of key tyrosine residues, crosses the blood-brain barrier, and shows antitumor activity in xenograft studies.
- Potent pan-ErbB inhibition with reported IC50 values of ~22 nM (EGFR), 38 nM (ErbB2), and 21 nM (ErbB4).
- ATP-competitive mechanism of action.
- Demonstrated antitumor activity in human tumor xenograft models.
- Crosses the blood-brain barrier, enabling central nervous system studies.
- Provided as the hydrochloride salt; molecular weight 519.42 and formula C24H28Cl2N6O3.
- High purity (~98.4% by HPLC), suitable for in vitro and in vivo research.
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