Medchemexpress LLC JNK-IN-8 (JNK Inhibitor XVI) | 1410880-22-6 | 99.7% | 507.59 | 200 MG

Supplier:  Medchemexpress LLC 200MGHY13319

JNK-IN-8 (JNK Inhibitor XVI) is a potent inhibitor of JNK, demonstrating IC50 values of 4.7 nM for JNK1, 18.7 nM for JNK2, and 1 nM for JNK3. It inhibits the phosphorylation of c-Jun, a direct substrate of JNK kinase, with EC50s of 486 nM in HeLa cells and 338 nM in A375 cells. This compound also exhibits exceptional selectivity, as evidenced by KinomeScan and enzymatic profiling, making it a suitable tool for investigating JNK-dependent biological phenomena. JNK-IN-8 is a selective pan-JNK inhibitor that covalently targets Cys154 via an N,N-dimethyl butenoic actemide warhead.

• Potent JNK inhibitor with IC50s: JNK1 (4.7 nM), JNK2 (18.7 nM), and JNK3 (1 nM).
• Inhibits phosphorylation of c-Jun.
• Demonstrates high selectivity based on KinomeScan and enzymatic profiling.
• Covalently targets Cys154 through an N,N-dimethyl butenoic actemide warhead.

Catalog No. 50-003-65667