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Cayman Chemical JNK InhIbItr VIII 50mg
Supplier: Cayman Chemical 1594650 MG
An inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively); selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all); inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM); inhibits NGF-induced neuronal growth and proNGF-induced neurotoxicity of primary mouse superior cervical ganglion neurons at 10 µM; reduces apoptosis induced by GPX1 siRNA knockdown in HeLa cells at 10 µM
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