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Cayman Chemical JPH203hydrochlorIde 10mg
Supplier: Cayman Chemical 3605310 MG
An inhibitor of LAT1 (IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter); selective for LAT1 over LAT2 (IC50 = >10 μM); inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively); induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and PARP in YD-38 oral cancer cells at 3 mM; reduces tumor growth in an HT-29 mouse xenograft model at 6.3, 12.5, and 25 mg/kg
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