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Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.89% | 610.01 | 50 MG
Supplier: Medchemexpress LLC HY138691A50MG
JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. It increases H3K4me3 and can be used for the research of multiple myeloma.
- Increases global H3K4me3 levels in cells.
- Inhibits cell growth in a dose- and time-dependent manner (IC50=0.42 μM).
- Induces G1 cell-cycle arrest.
- Exhibits anti-multiple myeloma activity in vivo.
- Leads to increased H3K4me3 levels and reduced MYC immuno-staining.
- Significantly reduces tumor burden in mouse models.
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