Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Vector Biolabs Jun B proto-oncogene Adenovirus (Ad-JUN B)
Supplier: Vector Biolabs 1535
The activator protein-1 (AP-1) transcription factor consists of either Jun homodimers or Fos/Jun heterodimeric complexes, which bind the palindromic TRE sequence TGA(C/G)TCA. The Jun family includes c-Jun, Jun B and Jun D, while the Fos gene family members include c-Fos, Fos B, Fra-1 and Fra-2. In addition, certain ATF/CREB proteins form leucine zipper dimers with Fos and Jun, which exhibit different specificities for AP-1 and CRE DNA motifs. AP-1 transcription factor components are subject to regulation by both phosphorylation and by chemical oxidation of specific cysteine residues mapping within the DNA binding domains of Fos and Jun. Oxidation is reversible by a cellular redox/DNA repair protein designated Ref-1 (redox factor 1). JAB1 (Jun-activation domain-binding protein 1) potentiates transcription by either c-Jun or Jun D.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?