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Eurofins Discoverx PathHunter Jurkat SIRPa Signaling Cell Line, 2 vials. (93-1135C19)
Supplier: Eurofins Discoverx 931135C19
The PathHunter SIRPa Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. CD47) based activation of SIRPa receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged SIRPa target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
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