Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC JW 55 664993-53-7 10mg
Supplier: Apexbio Technology LLC A452910
JW 55 (CAS 664993-53-7) is a small-molecule inhibitor that targets the poly(ADP-ribose) polymerase (PARP) domains of tankyrase 1 and tankyrase 2 (TNKS1/2) with reported IC50 values of 1 9 M and 0 83 M respectively By inhibiting TNKS1/2 activity JW 55 stabilizes AXIN2 a component of the -catenin destruction complex leading to enhanced degradation of -catenin and suppression of canonical Wnt/ -catenin signaling In vitro JW 55 suppresses Wnt pathway activity in colorectal cancer cells harboring APC or -catenin mutations In vivo it reduces Wnt-driven phenotypes in Xenopus embryos and diminishes polyp formation in APC-mutant mice supporting its utility as a research tool in Wnt/ -catenin signaling and cancer biology
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?