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JW 55, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
Specifications
Quantity | 10 mg |
Formula Weight | 434.48 |
Percent Purity | >98% |
Chemical Name or Material | JW 55 |
Safety and Handling
Recommended Storage | Store at +4°C |
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