Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organic acids and derivatives
  6. Carboxylic acids and derivatives
  7. Carboxylic acid amides
  8. JW 55, Tocris Bioscience™

JW 55, Tocris Bioscience™

Catalog No. 451410
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
45-141-0 10 mg
45-145-0 50 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 45-141-0 Supplier R&D Systems Supplier No. 4514/10
This item is not returnable. View return policy

Description

Tankyrase inhibitor

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

Chemical Identifiers

CAS 664993-53-7
Molecular Formula C25H26N2O5
Molecular Weight (g/mol) 434.49
MDL Number MFCD03863265
InChI Key ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Synonym n-4-4-4-methoxyphenyl oxan-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl carbamoyl phenyl furan-2-carboxamide, qcr-64, n-4-4-4-methoxyphenyl oxan-4-yl methyl carbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-ylmethylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furamide, n-4-tetrahydro-4-4-methoxyphenyl-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furancarboxamide
PubChem CID 2946601
IUPAC Name N-[4-({[4-(4-methoxyphenyl)oxan-4-yl]methyl}carbamoyl)phenyl]furan-2-carboxamide
SMILES COC1=CC=C(C=C1)C1(CNC(=O)C2=CC=C(NC(=O)C3=CC=CO3)C=C2)CCOCC1

Specifications

Quantity 10 mg
Formula Weight 434.48
Percent Purity >98%
Chemical Name or Material JW 55

Safety and Handling

Recommended Storage Store at +4°C
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.