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Medchemexpress LLC JW67 | 442644-28-2 | 98.15% | 394.38 | 50 MG
Supplier: Medchemexpress LLC HY10844210MG
JW67 is a Wnt Signaling Inhibitor with an IC50 of 1.17 μM. It impacts the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. It also inhibits colorectal cancer cell growth.
- Inhibits canonical Wnt signaling
- Reduces active β-catenin
- Downregulates Wnt target genes
- Inhibits colorectal cancer cell growth
- Increases AXIN2 concentration
- Affects Wnt target gene expression
- Reduces cell growth in colon cancer cell lines
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