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Medchemexpress LLC K-01-162 | 677746-25-7 | 98.0% | C15H14BrN | 1 ML
Supplier: Medchemexpress LLC HY1453310MM/1ML
K 01-162, also known as K162, is an inhibitor designed to prevent the fibril formation of Aβ peptides and mitigate their neurotoxicity. This compound demonstrates binding affinity with Aβ42 peptide (EC50 of 80 nM) and directly with AβO (KD of 19 μM). It can penetrate the brain, making it a valuable tool for Alzheimer's disease research.
- Inhibits fibril formation of Aβ peptides
- Eliminates neurotoxicity of Aβ peptides
- Binds with Aβ42 peptide (EC50 of 80 nM)
- Binds directly to AβO (KD of 19 μM)
- Reduces intracellular AβO levels
- Blocks synaptic binding activity of AβO in mouse hippocampal neurons
- Attenuates amyloid load in vivo
- Capable of penetrating the brain
- Suitable for Alzheimer's disease research
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