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Cayman Chemical K 41498 trifluoroacetate sal
Supplier: Cayman Chemical 36417500 UG
A peptide antagonist of CRF2α and CRF2β (Kis = 0.66 and 0.62 nM, respectively, in HEK293 cells expressing the human receptors); selective for CRF2α and CRF2β over CRF1 (Ki = 425 nM in HEK293 cells expressing the human receptor); prevents urocortin-induced hypotension in rats at 1.84 UG, i.v; intrathecal administration decreases the mechanical paw withdrawal threshold in a complete Freund's adjuvant-induced rat model of nociception at 0.075-0.5 µmol
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