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Medchemexpress LLC K-Ras G12C-IN-4 | 2376328-55-9 | 99.2% | 10 MG
SDP

Catalog No. 5000341195
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K-Ras G12C-IN-4 is a potent covalent inhibitor of KRASG12C, intended for research use only.

  • Potent covalent inhibitor of KRASG12C.
  • Exhibits cytotoxicity in A549 cells (IC50 of 9.33 μM at 72 hrs).
  • Inhibits EGF-induced ERK1/2 phosphorylation in A549 cells (IC50 of > 10 μM at 4 hrs).
  • Shows cytotoxicity in MIA PaCa-2 cells (IC50 of 0.067 μM at 72 hrs).
  • Inhibits MAPK signaling (p-ERK) in MIA PaCa-2 cells (IC50 of 0.219 μM at 4 hrs).
  • Highly soluble in DMSO for in vitro studies (62.5 mg/mL).
  • Demonstrates suitable solubility for in vivo applications using various protocols.

Catalog No. 50-003-41195 Supplier Medchemexpress LLC Supplier No. HY12877110MG
May include imposed supplier surcharges.
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K-Ras G12C-IN-4 is a potent covalent inhibitor of KRASG12C, intended for research use only.

  • Potent covalent inhibitor of KRASG12C.
  • Exhibits cytotoxicity in A549 cells (IC50 of 9.33 μM at 72 hrs).
  • Inhibits EGF-induced ERK1/2 phosphorylation in A549 cells (IC50 of > 10 μM at 4 hrs).
  • Shows cytotoxicity in MIA PaCa-2 cells (IC50 of 0.067 μM at 72 hrs).
  • Inhibits MAPK signaling (p-ERK) in MIA PaCa-2 cells (IC50 of 0.219 μM at 4 hrs).
  • Highly soluble in DMSO for in vitro studies (62.5 mg/mL).
  • Demonstrates suitable solubility for in vivo applications using various protocols.

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