Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC K-Ras(G12C) inhibitor 12 1469337-95-8 5mg
Supplier: Apexbio Technology LLC B48765
K-Ras(G12C) inhibitor 12 (CAS 1469337-95-8) is an allosteric inhibitor targeting the K-Ras(G12C) mutant a GTPase implicated in various signal transduction pathways and commonly mutated in cancers This small molecule reduces the affinity of K-Ras(G12C) for GTP promotes covalent modification of the mutant protein and inhibits SOS-mediated nucleotide exchange In K-Ras(G12C)-mutant lung cancer cell lines (H1792 H358 H23 Calu-1) it disrupts C-Raf and B-Raf association with Ras decreases cell viability and induces apoptosis In H1792 cells the EC50 is 0 32 M K-Ras(G12C) inhibitor 12 is valuable for studies of Ras biology and targeted cancer research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?