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Apexbio Technology LLC K-Ras(G12C) inhibitor 9 1469337-91-4 5mg
Supplier: Apexbio Technology LLC B60025
K-Ras(G12C) inhibitor 9 (CAS 1469337-91-4) is a covalent small molecule that selectively targets the oncogenic K-Ras(G12C) mutant protein Acting as an allosteric inhibitor it irreversibly binds to the mutant K-Ras interfering with the binding of GTP and GDP and disrupts interactions with effector proteins such as B-Raf and C-Raf In vitro studies show that treatment with 10 M K-Ras(G12C) inhibitor 9 reduces viability and increases apoptosis in K-Ras(G12C)-mutant lung cancer cell lines including H1792 Calu-1 H358 and H23 This compound is a valuable research tool for investigating K-Ras-driven cancer signaling and mutant-selective therapeutic strategies
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