Medchemexpress LLC K-Ras ligand-Linker Conjugate 4 | 2378261-83-5 | 98.8% | 1 ML

Supplier:  Medchemexpress LLC HY13082210MM/1ML

K-Ras ligand-Linker Conjugate 4 incorporates a ligand for the K-Ras recruiting moiety and a PROTAC linker, designed to recruit E3 ligases such as VHL, CRBN, MDM2, and IAP. This conjugate is utilized in the synthesis of potent PROTAC K-Ras Degrader-1, which has demonstrated ≥70% degradation efficacy in SW1573 cells. PROTACs function by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.

• Incorporates a ligand for a K-Ras recruiting moiety
• Includes a PROTAC linker to recruit E3 ligases (VHL, CRBN, MDM2, IAP)
• Used in the synthesis of a potent PROTAC K-Ras degrader
• Demonstrates high degradation efficacy in SW1573 cells
• Utilizes the intracellular ubiquitin-proteasome system for selective protein degradation

Catalog No. 50-003-38540