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Medchemexpress LLC K-Ras ligand-Linker Conjugate 4 | 2378261-83-5 | 98.8% | 100 MG
Supplier: Medchemexpress LLC HY130822100MG
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for a K-Ras recruiting moiety and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). It can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), a potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
- Incorporates a ligand for K-Ras recruiting moiety
- Features a PROTAC linker to recruit E3 ligases
- Used in the synthesis of potent PROTAC K-Ras degrader
- Degrader exhibits ≥70% degradation efficacy in SW1573 cells
- Exploits the intracellular ubiquitin-proteasome system
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