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Medchemexpress LLC K-Ras ligand-Linker Conjugate 4 | 2378261-83-5 | 98.8% | 25 MG
Supplier: Medchemexpress LLC 25MGHY130822
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for the K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP. It can be used in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells. PROTACs consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates a ligand for the K-Ras recruiting moiety
- Includes a PROTAC linker that recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Can be used in the synthesis of PROTAC K-Ras Degrader-1
- For research use only
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