Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC K-Ras ligand-Linker Conjugate 4 | 2378261-83-5 | 98.8% | 50 MG
Supplier: Medchemexpress LLC HY13082250MG
K-Ras ligand-Linker Conjugate 4 integrates a ligand for K-Ras recruiting moiety and a PROTAC linker, which recruits E3 ligases (VHL, CRBN, MDM2, IAP). It is used in the synthesis of a potent PROTAC K-Ras degrader that demonstrates ≥70% degradation efficacy in SW1573 cells. PROTACs utilize the intracellular ubiquitin-proteasome system for selective degradation of target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- Incorporates a ligand for K-Ras recruiting moiety.
- Features a PROTAC linker to recruit E3 ligases.
- Used in the synthesis of potent protein degraders.
- Facilitates selective degradation of target proteins.
- Leverages the ubiquitin-proteasome system.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?