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Medchemexpress LLC K-Ras ligand-Linker Conjugate 6 | 2378261-89-1 | 50 MG
SDP

Catalog No. 5000340678
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K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP, enabling the use of this conjugate in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader exhibiting ≥70% degradation efficacy in SW1573 cells. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and another for the target protein.

  • Incorporates a ligand for K-Ras recruiting moiety
  • Features a PROTAC linker
  • Recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
  • Used in the synthesis of potent PROTAC K-Ras degraders
  • PROTACs utilize the ubiquitin-proteasome system
  • Selectively degrades target proteins

Catalog No. 50-003-40678 Supplier Medchemexpress LLC Supplier No. HY13099150MG
May include imposed supplier surcharges.
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K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP, enabling the use of this conjugate in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader exhibiting ≥70% degradation efficacy in SW1573 cells. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and another for the target protein.

  • Incorporates a ligand for K-Ras recruiting moiety
  • Features a PROTAC linker
  • Recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
  • Used in the synthesis of potent PROTAC K-Ras degraders
  • PROTACs utilize the ubiquitin-proteasome system
  • Selectively degrades target proteins

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