Medchemexpress LLC K-Ras ligand-Linker Conjugate 6 | 2378261-89-1 | 50 MG

Supplier:  Medchemexpress LLC HY13099150MG

K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP, enabling the use of this conjugate in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader exhibiting ≥70% degradation efficacy in SW1573 cells. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and another for the target protein.

• Incorporates a ligand for K-Ras recruiting moiety
• Features a PROTAC linker
• Recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
• Used in the synthesis of potent PROTAC K-Ras degraders
• PROTACs utilize the ubiquitin-proteasome system
• Selectively degrades target proteins

Catalog No. 50-003-40678