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Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.8% | 277.35 | 5 MG
Supplier: Medchemexpress LLC 5MGHY19966
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5, with an IC50 of 1.3 μM. It specifically induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint, leading to mitotic cell death in cancer cells without affecting normal cells. It also shows antitumor activity in ovarian and colon cancer xenograft models in vivo.
- ATP-uncompetitive inhibitor of kinesin Eg5
- Induces mitotic arrest and growth inhibition
- Activates the Mad2-mediated spindle checkpoint
- Induces mitotic cell death in cancer cells at 5 μM
- Shows antitumor activity in A2780 ovarian and HCT116 colon cancer xenograft models
- Displays no neurotoxic side effects in mice
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