Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Kasugamycin hydrochloride (Ksg hydrochloride) | 19408-46-9 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HYB1864A50MG
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that exhibits anti-infective activity by binding to 30s and 70s ribosomes, without affecting the 50s subunit. Its mechanism involves mimicking mRNA nucleotides, which consequently disrupts tRNA binding and hinders canonical translation initiation. This compound has also been observed to enhance the sensitivity of mycobacteria to Rifampicin in both in vitro settings and mouse infection models.
- Inhibits P-site tRNA binding by destabilizing mRNA.
- Decreases mistranslation rates of asparagine-to-aspartate and glutamine-to-glutamate.
- Reduces mycobacterial rifampicin phenotypic resistance in wild-type and high mistranslating gatA mutant mycobacterial strains.
- Leads to rapid clearance of *M. tuberculosis* in lung burden in Mtb-infected mice.
- Increases Rifampicin susceptibility by 30-fold.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?