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Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.77% | 360.33 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY137478A

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KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It shows >50-fold selectivity over other CDK kinases and exhibits potent anti-tumor activity.

  • Potent and selective CDK9 inhibitor.
  • Orally active.
  • Exhibits >50-fold selectivity over other CDK kinases.
  • Possesses potent anti-tumor activity.
  • Reduces downstream phosphorylation of RNA Pol II.
  • Downregulates global androgen receptor (AR) protein levels.
  • Decreases nascent transcription and depletes short half-life transcripts.
  • Well tolerated and significantly reduces tumor burden in xenograft models.

Catalog No. 50-003-51837


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