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Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 50 MG
Supplier: Medchemexpress LLC 50MGHY137478A
KB-0742 dihydrochloride is a potent, selective, and orally active inhibitor of CDK9/cyclin T1, demonstrating an IC50 of 6 nM. It exhibits over 50-fold selectivity against other CDK kinases and shows significant anti-tumor activity. This compound has been shown to reduce downstream phosphorylation of RNA Pol II at Ser2, Ser7, and Ser5, and to diminish global androgen receptor protein levels in prostate cancer cells. It also displays antiproliferative effects in various cancer cell lines, such as prostate cancer and leukemia.
- Potent and selective CDK9 inhibitor.
- Orally active with significant anti-tumor efficacy.
- Exhibits high selectivity for CDK9/cyclin T1 over other CDK kinases.
- Induces significant reduction of RNA Pol II phosphorylation.
- Demonstrates antiproliferative activity in cancer cell lines.
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