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Cayman Chemical KB-0742hydrochlorIde 5mg
Supplier: Cayman Chemical 397725 MG
A Cdk9 inhibitor (IC50 = 6 nM); selective for Cdk9 over Cdk1-8 (IC50s = 397->10,000 nM) and Cdk12-19 (IC50s = 372->10,000 nM); induces cell cycle arrest at the G1 phase and apoptosis in BT-20, BT-549, MDA-MB-231, MT-3, and Hs 578T TNBC cells from 0.64-7.73 µM; reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg
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