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Medchemexpress LLC KB-R7943 mesylate | 182004-65-5 | C17H21N3O6S2 | 1 ML
SDP

Catalog No. 5000376637
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KB-R7943 mesylate is an inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with an IC50 of 5.7 ± 2.1 μM. It induces cancer cell death by activating the JNK pathway and blocking autophagic flux.

  • Blocks NMDAR-mediated ion currents.
  • Inhibits NMDA-induced increase in cytosolic Ca2+ (IC50 = 13.4 ± 3.6 μM).
  • Accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons.
  • Depolarizes mitochondria in a Ca2+-independent manner.
  • Inhibits 2,4-dinitrophenol-stimulated respiration (IC50 = 11.4 ± 2.4 μM).
  • Dose-dependently and reversibly blocks ion currents elicited by NMDA.
  • Inhibits ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
  • Inhibits both IhERG and native IKr (IC50 values of ~89 nM and ~120 nM, respectively).

Catalog No. 50-003-76637 Supplier Medchemexpress LLC Supplier No. HY1541510MM/1ML
May include imposed supplier surcharges.
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KB-R7943 mesylate is an inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with an IC50 of 5.7 ± 2.1 μM. It induces cancer cell death by activating the JNK pathway and blocking autophagic flux.

  • Blocks NMDAR-mediated ion currents.
  • Inhibits NMDA-induced increase in cytosolic Ca2+ (IC50 = 13.4 ± 3.6 μM).
  • Accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons.
  • Depolarizes mitochondria in a Ca2+-independent manner.
  • Inhibits 2,4-dinitrophenol-stimulated respiration (IC50 = 11.4 ± 2.4 μM).
  • Dose-dependently and reversibly blocks ion currents elicited by NMDA.
  • Inhibits ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
  • Inhibits both IhERG and native IKr (IC50 values of ~89 nM and ~120 nM, respectively).

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