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Cayman Chemical KB-R7943mesylate 5mg
Supplier: Cayman Chemical 163525 MG
A farnesyltransferase inhibitor that blocks the post-translational lipid modification of oncogenic Ras isoforms H-Ras N-Ras and K-Ras (IC50s 1.9 2.8 and 5.2 nM respectively) and Rheb (IC50 10-100 nM) demonstrates potent dose-dependent oral activity in an array of human tumor xenograft models including tumors originating from colon lung pancreas prostate and urinary bladder
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