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AdipoGen Kdo2-Lipid A (ready-to-use), AdipoGen Life Sciences. Chemical. CAS: 123621-04-5
Supplier: AdipoGen AGCU10001M001
Kdo2-Lipid A (ready-to-use), AdipoGen Life Sciences. Chemical. CAS: 123621-04-5 (free base). Formula: C110H198N2Na4O39P2. MW: 2326.7. Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant). Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy.
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